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Pueraria mirifica Quick menu History of Pueraria mirifica Research of Pueraria mirifica Composition of Pueraria mirifica Effect of using Pueraria mirifica Application of Pueraria mirifica Case Studies of Pueraria mirifica History of Pueraria mirifica Local communities in Thailand have used Pueraria Mirifica for well over one hundred years, specifically for its rejuvenating qualities, The belief in the rejuvenating properties of Pueraria Mirifica has been passing down from one generation to another and more recently through the publication by Luang Anusan Suntara. In May 1931, Luang Anusan Suntara published a pamphlet on the subject of "Kwao Krua" describing different ways of preparing folk medicine using Pueraria Mirifica and the claims of its rejuvenating power. It is stated in the pamphlet that Pueraria Mirifica can: Serve as an anti-wrinkle agent for aged and wrinkled skin Darken white hair, and increase hair growth Alleviated cataract problems Help with memory loss Increase energy and vigor, more reflexive bodily movements Increase blood circulation Increase appetite, and - Alleviate sleep disorders In 1932, Dr. A.F.G. Kerr, the Director of the Botanical Section of the Journal of the Siam Society, directed the attention of the scientific community to the fact that the tuberous roots of a Thai plant called "Kwao Krua", mistakenly identified then as Butea Superba, were considered to be of value as a rejuvenating drug. Dr. Kerr was the first to create international awareness of the rejuvenating qualities of this plant, which subsequently led to the isolation of a potent phyto-estrogen that is unique to this plant only and to the identification of the plant as Pueraria Mirifica in 1952. Serves as the “Fountain of Youth” for aged men and women Back to top Research of Pueraria mirifica Our researcher has started research on Pueraria Mirifica since 1991 and then later on Butea Superba. Pueraria Mirifica (White Kwao Krua) is Thailand’s endemic species found mainly in the northern and western part of Thailand and has local name as “White Kwao Krua”. The Thai vine herbal plant is grown in association with the moderate-size trees ranking from timber wood to bamboo in the deciduous rain forest. Pueraria Mirifica Study The enlargement underground tuber accumulates “phyto-estrogens” (Hormone from Plant) comprising isoflavones (daidzin, daidzein, genistin, genistein and puerarin) and others such as miroestrol and its derivatives, beta-sitosterol, stigmasterol, coumestrol, puerarin, mirificoumestan, kwakhurin and mirificin. The scope of our study is biotechnology of the White, Red and Black Kwao Krua. Our study has be done by traveling to many forests in many parts of Thailand to search and select for the right and best cultivar of these herbs by rely on botanical characteristic, chemical analysis, consumption history, toxicology test as well as laboratory test and clinical trial. The result of study under controlled by researcher According to our research has revealed that Pueraria Mirifica and Butea Superba are safe to be used in human in certain dosage as well as consumption period. Our researcher has been conducting a series of researches covering the chemical analysis, tissue culture, mass propagation, cultivar improvement, production, product development and testing and so on for 9 years. Because this finding showed a great impact to the herbal food, cosmetic, drug and beverage industries, so he has submitted patents concerned these findings and application in both Thailand and abroad. The result shows that our selected Pueraria Mirifica cultivar contains very high isoflavones contents and showing high anti-mutagenic effects as well as high killing effects to human mammary cancer cell line. Nowadays nutritionists recommend the consumer to consume isoflavones regularly for the purpose of cancer protection normally found on post-menopausal and people who are Hormone Imbalance. What is benefit of Miroestrol and its derivatives? Miroestrol and its derivatives are also precious chemicals in the White Kwao Krua which promote estrogenic and monogenic effects to various tissues as Breast Enlargement or Breast Tissue Reformation. (See the result of Clinical study about Breast Enlargement by Pueraria Mirifica herbal and FAQ Breast Enlargement Forum ) and organs such as uterus, ovary and skin as HRT (Hormone Replacement Therapy) More than 20 kinds of chemical substances were analyzed from Pueraria and they were divided in to 3 groups. 1. A mild action substances in the group of Sterol. 2. The substances in Isoflavonoid groups which also be found in soybean, a commonly used health nourishment in Japanese food and is proven to be anti-breast cancer. 3. An acute substances of Coumestan group What is different between Soya and Pueraria Mirifica? Soya, the main oriental food and Alfalfa, the western health food products contains lower amount of phyto-estrogens especially there is no miroestrol and its derivatives. Their benefit to the body is far less than that of Pueraria Mirifica. The researches confirm that these chemicals are potent anti-breast cancer, anti-prostate hyperplasia, anti-colon cancer, anti-osteoporosis and also anti-cardiovascular disease via the potent reduction of blood cholesterol and also anti-menopausal syndrome. Back to top Composition of Pueraria mirifica The compounds that make Pueraria Mirifica different from any other phyto-estrogen containing plants in the Family Leguminous are Miroestrol and Deoxymiroestrol, which possess highest estrogenic activity among the known phyto-estrogens due to structural similarity to estradiol, Miroestrol was actually the first compound isolated from this plant by a group of German chemists in 1940, but the plant had been mistakenly reported then as Butea Superba. It was later on classified as a new plant called Pueraria Mirifica Airy Shaw et Suvatabhandu. The isolation and identification of deoxymiroestrol from the root of Pueraria Mirifica has just been reported in the February 2000 issue of the Journal of Natural Products, The authors proposed that since deoxymiroestrol is easily oxidized to miroestrol, deoxymiroestrol, not the previously reported miroestrol, is more likely to be the actual chemical constituent of Pueraria Mirifica. However, it is very likely that the two phyto-estrogens coexist in the root of this plant. As shown below, the chemical structures of two compounds are very similar to that of estradiol, the main human estrogen. In addition to miroestrol and deoxymiroestrol, Pueraria Mirifica also contains other chemicals that belong to isoflavones and Coumestan groups of phyto-estrogens, e.g., Genistein, Daidzein, Daidzin, Genistin, and Coumestrol that are usually found in soybeans (Table 1). However, the estrogenic activity of Miroestrol and Deoxymiroestrol is much more potent than that of soy isoflavones. Table 1: Chromene, Isoflavonoid and Coumestan derivatives in Pueraria Mirifica Chromene Isoflavones Isoflavones glycosides Coumestan Miroestrol Daidzein Daidzin Coumestrol Deoxymiroestrol Genistein Genistin Mirificoumestan Kwakhurin Mirificin Mirificoumestan glycol Kwakhurin hydrate Puerarin Mirificoumestan hydrate Puerarin-6” monoacetate What is benefit effects of Chemical composition from Pueraria Mirifica? While Soya and Alfalfa contains low amount and low estrogenic of the phyto-estrogens, many researches pointed out the benefit effects of those chemicals, especially to act as a Potent Anti-Breast Cancer, Anti-Prostate Cancer, Anti-Colon Cancer, Anti-Cardio-Vascular disease via the reduction of blood cholesterol and also Anti-Menopausal Syndrome. The phyto-estrogens in the Pueraria Mirifica (White Kwao Krua) is more concentrated and higher efficacy. By this distinguish property, biotechnology application has shown up for this herb. Back to top Effect of using Pueraria mirifica High Isoflavones the phyto - anticancer After many years of species selection, enrich with high isoflavones, the most interesting phyto-estrogens has been selected and submitted to organic farming in a huge area to guarantee the unique benefit of the phyto-estrogens. Now this species is manufactured into our vast variety of Products |, and distributed in Japan, China, Thailand, Europe and U.S.A. Our Selected Species Phyto-estrogens especially isoflavones, enriched in Pueraria Mirifica only our selected species which this selected grade can make us differentiate from the other supplier with chemical compound approval If intake at a right dosage will support healthy female characteristics, bone structure, cardio - vascular system, breast and skin appearance in women and also health prostate function and keeps hair pattern in men. According to our study, our researcher recommend women who are lack of endogenous estrogen including menopausal women and also mature men who are facing aging problems, should intake White Kwao Krua regularly to keep rejuvenate and the tonic felling. What is Phyto-estrogen? The term "natural" can refer to the source of the hormone or more importantly, it can mean that it is natural to a woman’s body; that its chemical structure is identical to the hormones produced by the human body. The estrogens used in our formulation are the exact same molecules as the ones produced by a woman’s body. They are bio-identical. This means a woman’s body recognized it just as if she had produced it herself. It is not treated as a "foreign" molecule, her body can use it correctly, and side effects are minimal, or even eliminated! Just as the hormone needs to be "bio-identical" to be natural, it should also be given in natural proportions. The term "estrogens" actually refers to several hormones, estriol, estrone, and estradiol being the ones natural to a woman’s body. As a young woman, each is produced in certain amounts. When the body slows down making these estrogens, as in menopause, they should not only be replaced, but also in natural quantities. Our formulation provides all three estrogens, in the normal proportions, to basically imitate what a woman’s body produced before menopause. What is natural hormone? The term "natural" can refer to the source of the hormone or more importantly, it can mean that it is natural to a woman’s body; that its chemical structure is identical to the hormones produced by the human body. The estrogens used in our formulation are the exact same molecules as the ones produced by a woman’s body. They are bio-identical. This means a woman’s body recognized it just as if she had produced it herself. It is not treated as a "foreign” molecule, her body can use it correctly, and side effects are minimal, or even eliminated! Just as the hormone needs to be "bio-identical" to be natural, it should also be given in natural proportions. The term "estrogens" actually refers to several hormones, estriol, estrone, and estradiol being the ones natural to a woman’s body. As a young woman, each is produced in certain amounts. When the body slows down making these estrogens, as in menopause, they should not only be replaced, but also in natural quantities. Our formulation provides all three estrogens, in the normal proportions, to basically imitate what a woman’s body produced before menopause. What could be more natural? One more hormone to consider “progesterone” that same young woman produced progesterone along with her three estrogens, and that same woman in menopause has quit making progesterone. Our formulation includes progesterone, also from natural sources and bio-identical, for several reasons. By replacing what is lost, a woman is getting back to what is most natural for her body. Progesterone actually helps the body use the estrogens better, so we can use the least amount of estrogens to be effective. Progesterone has been shown to actually build bone, act as a natural antidepressant, serve as a source of other hormones lost to aging; basically, making things more balanced. Back to top Application of Pueraria mirifica Pueraria Mirifica has long been traditionally prepared in the form of pills for oral intakes. Currently, the dried roots are finely ground, sometimes mixed with other medicinal herbs, packed in capsules and marketed as a dietary supplement; however, for some distributors, the capsules are prepared from the root extract. The formulation that includes ingredient list and content of each ingredient varies from one supplier to another. Pueraria Mirifica in the form of extract has been introduced just recently. With modern extraction technology, the extract from dried roots is standardized and prepared in the form of powder and solution, the extract solution is used in cosmetic industry such as preparation of breast cream, eye gel, and skin moisturizer. The extract powder is used as a dietary supplement similarly to the traditional method, but the product has more uniformity due to the advantage of standardization. When Pueraria Mirifica is taken as a dietary supplement, its phyto-estrogen constituents will naturally alleviate symptoms occurring as a result of the aging process and a deficiency in estrogen levels, e.g., sagging breasts, wrinkled skin, bone loss, gray hair, etc. These aging signs and symptoms will, to a certain extent, be reversed, When applied topically to the skin, Pueraria Mirifica will be beneficial to that respective part of the body. Various forms and preparations of Pueraria Mirifica should provide an effective and inexpensive alternative to women who wish to take charge of their own health and to enhance their beauty or utilize Pueraria Mirifica for many cosmetic purposes. With regard to the safety and efficacy of dermal preparations of Pueraria Mirifica extract, standard dermal toxicity tests were performed in various animal species as well as in humans, and no toxicity was observed, Moreover, the efficacy of breast cream was recently evaluated in a large group of human volunteers. Back to top Case Studies of Pueraria mirifica Clinical Study & Practice on Pueraria Mirifica Herbal Breast Enlargement by Pueraria Mirifica. 1) In 90% of women, the phyto-estrogen from Pueraria herbal will induce the increasing of the cell turgidity but not cell multiplication or proliferation in their chest. 2) Breast Enlargement will be in good efficiency if one takes calcium as supplement for foods and does good exercise for the chest. It is recommended to drinking a lot of milk while applying Kwao Krua Products is recommended. 3) According to the research results, intake of Pueraria Mirifica herbal in the form of fine powder is the best way to let the body absorb the natural ingredients from the herb. But it should be taken only in small milligrams because the natural phyto-estrogens inside the Pueraria Mirifica is thousand times higher that a pea which will be too much for the human body to intake. The breast enlargement & firmness by ingestion of Pueraria Mirifica Products. 3.1) Breast enlargement occurs by the development of the mammary tissue that lengthens and branches the ducts that connects to the nipple whereas increasing numbers of fatty tissues and ligaments will provide support and shape of the breasts. As these ducts branch out from the nipple into the interior of the breast, ending in clusters of the lobules, the results will be fuller and firmer breasts. Moreover, exterior Pueraria Mirifica Products | helps maintain the collagen and stimulates developing new cells in skin, which improves the breast skin and maintains a natural look. 3.2) Response to Pueraria Mirifica product varies from person to person it is also due to their physiological conditions and genetic background. This is the reason why 10 % of the users do not respond to the Pueraria Mirifica Products. 3.2) Response to Pueraria Mirifica product varies from person to person it is also due to their physiological conditions and genetic background. This is the reason why 10 % of the users do not respond to the Pueraria Mirifica Products |. For the users who are effective to the Pueraria Mirifica, their breasts will be enlarged at a rate of 1/2 to 1 inch for before the breasts reaches up to the limited peak size and the duration will last 2-3 months. 3.3) In some cases user’s breasts will enlarge to 2.5 cm within 5 days this is so because anyone who has a physical structure with a large breast will have a quick response but their breasts will reach its peak size quickly. In the other hand, a person who has small breast will have a slow response to the Pueraria Mirifica which will take more time to reach the peak point. 3.4) Aging person should apply a low ingested dose which will nourish the physical health not depending on sex and has no effects on breast enlargement. 3.5) Below 20 years old girl should be prohibited to use our Products | this is to allow her body system to grow up into fully maturity before taking any treatments. 3.6) Anybody who has a record of hyperthyroidism or thyroid related disease, ovary and uterus diseases and breast tumor or cancer is recommended not to use the Products | it is because there is no scientific proof that Pueraria Mirifica Products | will or will not cause any side effects to cancer. 4) The phyto-estrogen will act as female hormone, so it will work antagonistic way when apply in man (may decrease the genital size). However in aging person the intake at low dose will nourish the physical health not depending on sex. In the clinical research, the ingest after breakfast and before going to bed only one capsule a day nourishes the body to be in good health, skin, hair, and strengthens bones. This is also good for all aging person which low dose of the supplement has no effect on breast enlargement. 5) The ingest of Pueraria capsule twice as much as the mentioned above results in a tight feeling on your breast first and later your breast will be enlarged. The enlargement process will be continued at a level response before termination. 5.1) the response will be reached the peak and the effect will be changed to breast firmness. It should be noticed that the intake of the first capsule of Pueraria product should be concurrently with the first day of menstruation. 5.2) the intake of Pueraria should be continued for fifteen days consecutively and then be terminated. Next round of intake Pueraria will start again at the first day of next menstruation and continue the same way. 5.3) the maximum dose should not over 4 capsule a day. 6) For Pueraria cream product 2-3 cm of cream from tube is enough. Pueraria cream after spreading on your hand is rubbed by your finger on your breast from base to nipple in circular manner twice a day as of capsule type. The use of Pueraria product in both capsule and cream should be continued for 6 months. After that, the dosage can be decreased in half and the breast will still be maintained at the peak level. Back to top

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